Transforming growth factor-beta and its receptors in scleroderma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 415-421, 2009.
Article
de Zh
| WPRIM
| ID: wpr-259289
Bibliothèque responsable:
WPRO
ABSTRACT
The hallmark of scleroderma is fibrosis by excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs. Increasing evidence suggests that overexpression of transforming growth factor-beta (TGF-beta) and its receptors play a key pathogenic role in the development of tissue fibrosis in scleroderma. TGF-beta is known to induce the expression of ECM proteins in the pathogenesis of fibrosis in systemic sclerosis. Investigations into TGF-beta pathways will suggest new treatment strategies for fibrotic diseases.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Sclérodermie systémique
/
Fibrose
/
Protéines de la matrice extracellulaire
/
Facteur de croissance transformant bêta
/
Récepteurs TGF-bêta
/
Matrice extracellulaire
/
Fibroblastes
/
Métabolisme
Limites du sujet:
Animals
/
Humans
langue:
Zh
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2009
Type:
Article