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Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma / 中国实验血液学杂志
Article de Zh | WPRIM | ID: wpr-259576
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was purposed to detect the expressions of β-catenin and P-GSK-3 β in Wnt signaling pathway of patients with mantle cell lymphoma(MCL), and investigate its relationship with the pathogenesis of MCL.</p><p><b>METHODS</b>The expression levels of β -catenin protein and P-GSK-3 protein in mantle cell lymphoma and hyperplastic lymphadenitis were detected by using anti-β-catenin, P-GSK-3β polyclonal antibody and S-P staining technique.</p><p><b>RESULTS</b>The abnormal expression of β-catenin protein(73.33%) in mantle cell lymphoma group was significantly higher than that (6.7%) in reactive lymph node hyperplasia group (P<0.05); and the positive rate of P-GSK-3 β(66.67%) in mantle cell lymphoma group was significantly higher than that (16.67%) in reactive hyperplasia of lymph node group (P<0.05). Spearman correlation analysis showed that there was obvious positive correlation (R=0.852, P<0.01).</p><p><b>CONCLUSION</b>The abnormal high expressions of β-catenin and P-GSK-3 β protein have been confirmed to appeare in mantle cell lymphoma.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Transduction du signal / Lymphome à cellules du manteau / Glycogen Synthase Kinase 3 / Bêta-Caténine / Voie de signalisation Wnt / Glycogen synthase kinase 3 beta Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Transduction du signal / Lymphome à cellules du manteau / Glycogen Synthase Kinase 3 / Bêta-Caténine / Voie de signalisation Wnt / Glycogen synthase kinase 3 beta Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article