Expression and clinical significance of nuclear factor κB/B cell lymphoma-2 signal pathway and glycogen synthase kinase 3β in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 11-15, 2015.
Article
Dans Zh
| WPRIM
| ID: wpr-261147
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study aims to examine the expression of nuclear factor κB (NF-κB)/B cell lymphoma-2 (Bcl-2) signal pathway and glycogen synthase kinase 3β (GSK-3β) in oral squamous cell carcinoma (OSCC) and provide references for the early diagnosis and prognosis evaluation of OSCC.</p><p><b>METHODS</b>A total of 55 cases of OSCC and 10 cases of paracan- cerous mucosa were examined in this study. Their expressions of GSK-3β, NF-κB and Bcl-2 were detected using the SP me- thod immunohistochemistry. The correlation between their expression in OSCC and the clinical and pathological peculiarity of OSCC was analyzed.</p><p><b>RESULTS</b>The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC were significantly higher than that in paracancerous mucosa (P < 0.01). The expression of GSK-3β, NF-κB, and Bcl-2 had no obvious relationship with patient's age, sex, and clinical stages of the disease (P > 0.05). The expression of Bcl-2 was significantly correlated with the degree of tumor differentiation (P < 0.05), whereas the expression of GSK-3β and NF-κB in OSCC had no obvious relation- ship with the degree of tumor differentiation (P > 0.05). Strong positive correlations were observed among the expressions of GSK-3β, NF-κB, and Bcl-2 (P < 0.05).</p><p><b>CONCLUSION</b>The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC are sig- nificantly higher than that in paracancerous mucosa. Detecting GSK-3β, NF-κB, and Bcl-2 in OSCC may have implications in the early diagnosis and prognosis evaluation of OSCC.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la bouche
/
Transduction du signal
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Différenciation cellulaire
/
Lymphome B
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Facteur de transcription NF-kappa B
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Glycogen synthase
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Apoptose
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Tumeurs épidermoïdes
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Glycogen Synthase Kinase 3
Type d'étude:
Prognostic_studies
/
Screening_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
West China Journal of Stomatology
Année:
2015
Type:
Article