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Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome / 中国实验血液学杂志
Article de Zh | WPRIM | ID: wpr-263301
Bibliothèque responsable: WPRO
ABSTRACT
The effects of conventional treatment for myelodysplastic syndrome (MDS) are not remarkable to date, while only a minority of patients was eligible for allogeneic stem cell transplantation. As epigenetics plays a significant role during the occurrence and development of MDS, and histone deacetylase inhibitors (HDACI), a class of gene expression modulating drugs, are currently being developed for therapy of several types of solid tumor, more attention is paying to HDACI as potential therapy of MDS. This review summarizes briefly the rationale for HDACI use in MDS, the common mechanism of HDACI, the present state of the clinical efficiency, and future development in this field.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Syndromes myélodysplasiques / Utilisations thérapeutiques / Épigenèse génétique / Traitement médicamenteux / Inhibiteurs de désacétylase d'histone / Génétique Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Syndromes myélodysplasiques / Utilisations thérapeutiques / Épigenèse génétique / Traitement médicamenteux / Inhibiteurs de désacétylase d'histone / Génétique Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2012 Type: Article