Preparation and anti-oxidative activity of liposomal ferulic acid / 药学学报
Yao Xue Xue Bao
; (12): 1092-1096, 2007.
Article
de Zh
| WPRIM
| ID: wpr-268225
Bibliothèque responsable:
WPRO
ABSTRACT
Ferulic acid (FA) was loaded into liposomes via calcium acetate gradient with (80.2 +/- 5.2)% entrapment efficiency. The average sizes of blank liposome and FA liposome were about 155 nm and 154 nm, respectively. The zeta potential of blank liposome and FA liposome were (13.14 +/- 1.67) mV and (4.12 +/- 0.05) mV, respectively. Unilamellar vesicles were present in freeze-fracture electron microscopy. In the pharmacodynamic studies, the protective effect of liposomal ferulic acid on tBHP-challenged U937 cells was measured with the morphology of cell injury, mitochondrial transmembrane potential alternation and cell viability assay used as index. The results of MTT assay, microscopy indicated that FA liposomes exhibited greater antioxidant activity than FA solution on U937 cell.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Taille de particule
/
Pharmacologie
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Physiologie
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Vecteurs de médicaments
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Chimie
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Cholestérol
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Cellules U937
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Acides coumariques
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Liposomes
/
Potentiels de membrane
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Yao Xue Xue Bao
Année:
2007
Type:
Article