Expressions of epidermal growth factor receptor in primary nasopharygeal carcinoma and lymph node metastases / 南方医科大学学报
Journal of Southern Medical University
; (12): 949-951, 2009.
Article
de Zh
| WPRIM
| ID: wpr-268802
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of epidermal growth factor receptor (EGFR) in primary nasopharygeal carcinoma (NPC) and lymph node metastases.</p><p><b>METHODS</b>Archived samples of primary NPC and paired lymph node metastases from 86 patients were examined immunohistochemically for the protein expression of EGFR.</p><p><b>RESULTS</b>EGFR expression positivity was detected in the primary NPC and lymph node metastases at the rate of 73.3% and 60.5%, respectively, and primary and metastatic foci showed significant difference in the expression levels (P=0.001). A discrepancy of EGFR expression between the primary and metastatic foci was found in 25 patients, with a discrepancy rate of 29.1% (25/86).</p><p><b>CONCLUSION</b>The difference in EGFR expression between the primary and lymph node metastastic foci of NPC needs to be evaluated when performing EGFR-targeted therapies especially in advanced NPC cases.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Tumeurs du rhinopharynx
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Récepteurs ErbB
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Noeuds lymphatiques
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Métastase lymphatique
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Métabolisme
Limites du sujet:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2009
Type:
Article