Expression of HER-2/neu oncogene in hepatocellular carcinoma and the clinical implications / 南方医科大学学报
Journal of Southern Medical University
; (12): 326-328, 2010.
Article
de Zh
| WPRIM
| ID: wpr-269560
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of human epidermal growth factor receptor 2 (HER-2/neu) in hepatocellular carcinoma (HCC) patients and its clinical significance.</p><p><b>METHODS</b>The expressions of HER-2/neu were detected by SP immunohistochemistry method in 30 patients with HCC, 10 with portal cirrhosis of the liver and 10 with normal liver.</p><p><b>RESULTS</b>The positivity rate of HER-2/neu was markedly higher in HCC patients than in those with portal cirrhosis and normal liver (Chi(2)=6.482, P=0.032). The expression of HER-2/neu was closely correlated to portal cirrhosis of the liver (P=0.041), tumor invasion (P=0.028) and Edmondson grades (P=0.012). The average survival time was significant shorter in patients with HER-2/neu-positive tumor than in those with HER-2/neu-negative tumor (P=0.036).</p><p><b>CONCLUSION</b>The expression of HER-2/neu may play a role in the invasion, metastasis and progression of HCC. The patients positive for HER-2/neu in the HCC tissues have generally poor prognosis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Carcinome hépatocellulaire
/
Récepteur ErbB-2
/
Génétique
/
Tumeurs du foie
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Métabolisme
/
Métastase tumorale
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article