A preliminary pathological study on human allotransplantation / 中华创伤杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To observe the survival of hand allograft under the state of immunosuppression and the pathological changes of rejection in the recovery process.</p><p><b>METHODS</b>The biopsies of the skin, nerve, muscle, tendon and bone tissue of hand allografts during different stages from 1 day to 7 months after operation were observed using routine histological technique.</p><p><b>RESULTS</b>No significant changes due to rejection in skin, nerve, muscle and bone tissue were observed. But different degrees of weak rejective changes were found on the wall of blood vessels; in the muscle and nerve the reactions were markedly stronger than those found in skin tissues.</p><p><b>CONCLUSIONS</b>The rejection in deep tissues should be monitored in controlling the rejection of hand allograft.</p>