Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells / 药学学报
Yao Xue Xue Bao
; (12): 600-603, 2012.
Article
de Zh
| WPRIM
| ID: wpr-276274
Bibliothèque responsable:
WPRO
ABSTRACT
This study is to investigate the protective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells. While PC12 cells were exposed to 100 micromol x L(-1) corticosterone for 48 h, cell survival rate was reduced and lactate dehydrogenase (LDH) release increased. In parallel, corticosterone caused significant elevations of DNA fragmentation, [Ca2+]i and caspase-3 activity. However, when the PC12 cells were incubated with longistyline A (4.0, 8.0 and 16.0 micromol x L(-1)) in the presence of 100 micromol x L(-1) corticosterone for 48 h, the effects were evidently alleviated, but dose-dependent manner was not obvious. In summary, longistyline A could generate a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Phénols
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Plantes médicinales
/
Corticostérone
/
Structure moléculaire
/
Survie cellulaire
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Chimie
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Calcium
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Cellules PC12
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Feuilles de plante
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Yao Xue Xue Bao
Année:
2012
Type:
Article