Connexin 43 expression and interacellular communicating function in acute leukemia bone marrow stroma cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 679-682, 2007.
Article
de Zh
| WPRIM
| ID: wpr-276845
Bibliothèque responsable:
WPRO
ABSTRACT
This study was purposed to investigate the connexin 43 (Cx43) expression level in acute leukemia bone marrow stromal cells (ABMSCs) and normal bone marrow stromal cells (NBMSCs), and to explore the difference in communicating functions between these cells. The Cx43 expression levels of ABMSCs and NBMSCs were detected by using immunohistochemistry and computer gray scale assay, and the difference of gap junction intercellular communication (GJIC) was examined through dry transfer technique. The results showed that expression level of Cx43 in ABMSCs was lower than that in NBMSCs and its function of GJIC in ABMSCs was also weaker than that in NBMSCs. It is concluded that cell-cell communication function is lowered in ABMSCs.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Physiologie
/
Cellules de la moelle osseuse
/
Cellules cancéreuses en culture
/
Leucémies
/
Communication cellulaire
/
Maladie aigüe
/
Cellules stromales
/
Jonctions communicantes
/
Connexine 43
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2007
Type:
Article