Recombination within the human leucocyte antigen / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 427-430, 2005.
Article
de Zh
| WPRIM
| ID: wpr-280035
Bibliothèque responsable:
WPRO
ABSTRACT
Understanding with greater clearness the characteristics of recombination within the human leucocyte antigen(HLA) is of deep significance to gaining an insight into the evolutionary process of shaping HLA allelic diversity and ultimately the human resistance against diverse pathogens. Family studies and statistical analysis of recombination have provided estimations of recombination fractions across the major histocompatibility complex and have identified the potential recombination hotspots. Other characteristics such as haplotype specificity and sequence motifs have been intensively studied. The recombination fractions, hotspots and other characters are reviewed in this paper.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Recombinaison génétique
/
Haplotypes
/
Déséquilibre de liaison
/
Fréquence d'allèle
/
Génétique
/
Antigènes HLA
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2005
Type:
Article