Relationship between polymorphisms of vitamin D receptor gene and familial aggregation of HBsAg carriers / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 148-153, 2006.
Article
Dans Zh
| WPRIM
| ID: wpr-281243
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether -Taq I T/C and -Fok I C/T polymorphisms of vitamin D receptor (VDR) gene are associated with the familial aggregation of hepatitis B virus (HBV) infection.</p><p><b>METHODS</b>Based on a population-based case-control family design, 288 family members from 27 case families and 230 family members from 27 control families were recruited. VDR gene polymorphisms were analyzed. VDR-Taq I T/C and VDR-Fok I C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism.</p><p><b>RESULTS</b>The frequency of VDR-Taq I TT genotype in the case families was significantly higher than that in the control families (P < 0.05) , however, the frequency of VDR-Fok I CC genotype in the case families was significantly higher than that in the control families (P < 0.05). The frequency of family members carriying Taq I T-Fok I C haplotype in the case families was significantly higher than that in the control families (OR = 1.67, P < 0.05), however, the frequency of family members carrying Taq I C-Fok I T haplotype in the case families was significantly lower than that in the control families (OR = 0. 24, P < 0.05). The similar results were found in the familial biological kinship relatives with any HBV-infected makers.</p><p><b>CONCLUSION</b>VDR-Taq I and -Fok I gene polymorphisms are likely to play a substantial role in HBsAg familial aggregation.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pedigree
/
Polymorphisme génétique
/
Haplotypes
/
Études cas-témoins
/
Réaction de polymérisation en chaîne
/
Récepteur calcitriol
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Prédisposition génétique à une maladie
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Fréquence d'allèle
/
Génétique
/
Hépatite B
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2006
Type:
Article