The impact of platelet membrane autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura / 中华血液学杂志
Chinese Journal of Hematology
; (12): 619-621, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-283936
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impact of platelet membrane glycoprotein (GP)-specific autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>Modified direct monoclonal antibody immobilization of platelet antigen assay (MAIPA) was used to detect platelet GPIIb/IIIa and/or GPI b specific autoantibodies. All patients received oral dexamethasone 40 mg/d for 4 days.</p><p><b>RESULTS</b>The response rate of high-dose dexamethasone in GPIIb/IIIa and/or GPIb specific autoantibody-negative patients was significantly different from that of antibody-positive patients (P<0.05). The response rate of GPIIb/IIIa specific autoantibody-positive patients was lower than that of antibody-negative patients (P<0.05). GPIb specific autoantibody had no significant impact on the efficacy of high-dose dexamethasone (P>0.05).</p><p><b>CONCLUSION</b>Platelet membrane GPIIb/IIIa-specific autoantibody can be a potential negative indicator for ITP patients'response to high-dose oral dexamethasone.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Autoanticorps
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Sang
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Dexaméthasone
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Résultat thérapeutique
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Purpura thrombopénique idiopathique
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Complexe glycoprotéique IIb-IIIa de la membrane plaquettaire
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Complexe glycoprotéique GPIb-IX plaquettaire
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Utilisations thérapeutiques
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Traitement médicamenteux
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Allergie et immunologie
Limites du sujet:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2009
Type:
Article