UPLC-Q-TOF-MS analysis of naringin and naringenin and its metabolites in rat plasma after intragastrical administration of alcohol extract of exocarpium Citri grandis / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1580-1585, 2010.
Article
de Zh
| WPRIM
| ID: wpr-285323
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze naringin, naringenin and its metabolites in rat plasma after intragastric administration of exocarpium Citri grandis alcohol extract.</p><p><b>METHOD</b>Rat blood samples were collected 1.0 hour after oral administration of 50 g x kg(-1) exocarpium Citri grandis alcohol extract and analyzed by UPLC-Q-TOF with MS(E) function. The post-acquisition data were processed using Metabolynx.</p><p><b>RESULT</b>Naringin (M1), naringenin (M2), naringin-5-O-glucuronide (M3), naringin-4-O-glucuronide (M4), glucuronide conjugate of naringenin (M5), naringin-4-O-sulfate (M6), methylated conjugate of hydroxylated naringenin (M7), glucuronide and sulfate conjugate of naringenin (M8), glucuronide conjugate of hydroxylated naringenin (M9) in rat plasma were detected. M3, M4, M6 were first reported as the metabolites of naringin. M7, M9 were first reported as the metabolites of naringenin.</p><p><b>CONCLUSION</b>The results indicated that naringin, naringenin can be metabolited as the forms of glucuronidation, sulfation and naringenin can also be metabolited as the forms of methylation with hydroxylation and glucuronidation with hydroxylation in vivo after administration.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Spectrométrie de masse
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Sang
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Extraits de plantes
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Répartition aléatoire
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Chimie
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Voies d'administration de substances chimiques et des médicaments
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Chromatographie en phase liquide à haute performance
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Citrus
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Rat Sprague-Dawley
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Flavanones
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2010
Type:
Article