Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 104-107, 2014.
Article
Dans Zh
| WPRIM
| ID: wpr-286551
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.</p><p><b>METHODS</b>This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.</p><p><b>RESULTS</b>TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI 1.14-2.52).</p><p><b>CONCLUSION</b>The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Seuil auditif
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Haplotypes
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Études cas-témoins
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Facteurs de risque
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Asiatiques
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DNA (cytosine-5-)-methyltransferase
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DNA (Cytosine-5-)-methyltransferase 1
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Génétique
Type d'étude:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Année:
2014
Type:
Article