Effect of preoperative transcatheter arterial chemoembolization on the perioperative outcome of patients with hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 671-675, 2015.
Article
de Zh
| WPRIM
| ID: wpr-286743
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the surgical risk, perioperative outcome and the response of patients with hepatocellular carcinoma (HCC) after preoperative transcatheter arterial chemoembolization (TACE).</p><p><b>METHODS</b>A retrospective case-matched study was conducted to compare the characteristics and corresponding measures of patients in the preoperative TACE group and the control group without TACE. A total of 105 patients (82 patients with selective and dynamic region-specific vascular occlusion to perform hepatectomy for patients with complex hepatocellular carcinoma) was included in this study, in which 35 patients underwent TACE therapy, and a 1:2 matched control group of 70 subjects.</p><p><b>RESULTS</b>The patients of preoperative TACE therapy group had a higher level of γ-glutamyl transpeptidase before operation (119.52±98.83) U/L vs. (67.39±61.25) U/L (P=0.040). The operation time was longer in the TACE group than that in the control group but with a non-significant difference (232.60±95.43) min vs. (218.70±75.13) min (P=0.052). The postoperative recovery of liver function and severe complications in the preoperative TACE group were similar to that in the control group (P>0.05). There were no massive hemorrhage, biliary fistula and 30-d death neither in the treatment group and matched control group.</p><p><b>CONCLUSIONS</b>Preoperative TACE therapy has certain negative effect on liver function. It is preferable to use selective and dynamic region-specific vascular occlusion technique during hepatectomy and combine with reasonable perioperative treatment for this group of patients, that can ensure safety of patients and promote their rapid recovery.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thérapeutique
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Études cas-témoins
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Études rétrospectives
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Chimioembolisation thérapeutique
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Carcinome hépatocellulaire
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Récupération fonctionnelle
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Période préopératoire
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Durée opératoire
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Gamma-Glutamyltransferase
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Hépatectomie
Type d'étude:
Observational_studies
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Risk_factors_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Oncology
Année:
2015
Type:
Article