Application of spline-based Cox regression on analyzing data from follow-up studies / 中华流行病学杂志

ABSTRACT

With R,this study involved the application of the spline- based Cox regression to analyze data related to follow-up studies when the two basic assunptions of Cox proportional hazards regression were not satisfactory.Results showed that most of the continuous covariatcs contributed nonlincarly to mortality risk while the effects of three covariates were timc- depcndent.After considering multiple covariatcs in spline-based Cox regression,when the ankle brachial index (ABI) decreased by 0.1,the hazard ratio (HR) for all-cause death was 1.071.The spline-based Cox regression method could be applied to analyze the data related to follow-up studies when the assumptions of Cox proportional hazards regression were violatcd.