T-bet gene expression in acute graft versus host disease / 中华血液学杂志
Chinese Journal of Hematology
; (12): 458-461, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-291398
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of T-bet [a T helper 1 (Th1) lymphocyte transcription factor] gene expression in predicting acute graft-versus-host disease (aGVHD) and evaluate the correlation between T-bet gene and aGVHD.</p><p><b>METHODS</b>Twenty patients who underwent allogeneic stem cell transplantation (allo. HSCT) entered this study. The expression of T-bet gene was examined with reverse transcription (RT)-PCR in bone marrow samples collected from patients on the day before conditioning, and day 0, day 14, day 28, and day 42 after HSCT.</p><p><b>RESULTS</b>The expression level of T-bet in patients developed aGVHD was increased compared with that before conditioning (P = 0.043). The incidence of aGVHD was 91.7% in patients whose T-bet expression level was increased on day 14 after transplant while was 12.5% in those whose T-bet gene expression level was not increased on that day (P < 0.001).</p><p><b>CONCLUSION</b>Patients with increased expression levels of T-bet after allo-HSCT may have an increased possibility to develop aGVHD. T-bet expression level may serve as an advisable guide to the clinician in predicting aGVHD and monitoring treatment.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Facteurs de transcription
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ARN messager
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Valeur prédictive des tests
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Transplantation de cellules souches hématopoïétiques
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Protéines à domaine boîte-T
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Diagnostic
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Génétique
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Maladie du greffon contre l'hôte
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Métabolisme
Type d'étude:
Diagnostic_studies
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Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2004
Type:
Article