Gene expression profile in early differentiation of K562 cells induced by matrine / 中华血液学杂志
Chinese Journal of Hematology
; (12): 342-345, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-291416
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare gene expression profile in K562 cells induced by matrine, so as to screen for differentiation related genes.</p><p><b>METHODS</b>K562 cells were exposed to 0.1 mg/ml matrine for 3 hours, and gene expression profiles in matrine-treated and non-treated cells were studied by cDNA microarray.</p><p><b>RESULTS</b>From 8465 screened genes, 30 differentially expressed genes were found. Among them 18 showed decreased expression including oncogene and proto-oncogene, signal transduction gene, DNA binding and transcription gene etc, 12 showed increased expression including cell receptor gene, immune-associated gene, metabolism-associated gene etc in matrine-treated K562 cells as compared with that in non-treated cell.</p><p><b>CONCLUSION</b>The genes, that are closely associated with differentiation of can-cer cell, could be the potential targets for cancer treatment.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Quinolizines
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Régulation de l'expression des gènes tumoraux
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Différenciation cellulaire
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Cellules K562
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Séquençage par oligonucléotides en batterie
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Analyse de profil d'expression de gènes
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Biologie cellulaire
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Alcaloïdes
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Génétique
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2004
Type:
Article