The expression and clinical implication of plasma miR-328 in patients with atrial fibrillation / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the expression and clinical implication of plasma miR-328 in patients with atrial fibrillation (AF).</p><p><b>METHODS</b>Fifty-eight patients with AF (AF group 17 paroxysmal AF, 21 persistent AF, and 20 permanent AF) and 15 healthy volunteers (Control group) were included. General clinical data and related biochemical parameters were collected. Plasma miR-328 levels were detected with quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The correlation between plasma miR-328 and AF risk factors was analyzed.</p><p><b>RESULTS</b>(1) Compared with the control group, the expression level of plasma miR-328 was significantly elevated in AF group (fold 7.72 ± 9.32) (P < 0.05). (2) In AF group, the expression of plasma miR-328 was significantly different in different type of AF[paroxysmal AF with (1.98 ± 0.81), persistent AF with (6.57 ± 5.82) and permanent AF with (13.47 ± 12.29)] (P < 0.05), and which was increased in proportion to the duration of AF. (3) There was a positive correlation between plasma miR-328 level and left atrial diameter in the AF group (r = 0.310, P < 0.05).</p><p><b>CONCLUSION</b>miR-328 expression is significantly increased in patients with AF, which may be involved in the atrial remodeling process of AF.</p>