Association between Alu insertion polymorphisms and HLA class I alleles in Chinese Lisu and Nu ethnic populations / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 222-228, 2012.
Article
de Zh
| WPRIM
| ID: wpr-295502
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the frequencies of HLA-Alu repeat polymorphisms (AluMICB, AluTF, AluHJ, AluHG and AluHF) in Chinese Lisu and Nu ethnic populations.</p><p><b>METHODS</b>The frequencies of HLA-Alu repeat polymorphisms in above populations were determined with polymerase chain reaction (PCR). The associations between HLA-Alu repeat polymorphisms and HLA-A, HLA-B and HLA-C alleles were also analyzed. Phylogenetic trees were constructed with genetic distance calculated from the frequencies of HLA-Alu repeat polymorphisms.</p><p><b>RESULTS</b>Frequencies of AluTF*2 and AluHF*2 were different between the two populations (P< 0.05), while those of other three insertions were similar. The strength of association between HLA-Alus and HLA alleles were different (P< 0.05) in the two populations. Although AluMICB*2 were associated with HLA-B*56:01 in both populations, the association was stronger in Lisu population (74.0%) but moderate in Nu population (30.7%). HLA-Alus were associated with particular HLA subtypes, e.g., AluHG*2 with certain HLA-A*02 subtypes. By phylogenetic analysis, Lisu and Nu were clustered together with southern Chinese and Thai populations.</p><p><b>CONCLUSION</b>The distribution of HLA-Alus and the strength of associations between HLA-Alus and HLA class I alleles have varied between the two populations. Study of this association may facilitate identification of origins, evolution, progenitor haplotypes and recombination within the HLA class I region.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phylogenèse
/
Polymorphisme génétique
/
Gènes MHC de classe I
/
Séquences Alu
/
Asiatiques
/
Allèles
/
Génétique
Limites du sujet:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2012
Type:
Article