Outcomes of imatinib and allogeneic hematopoietic stem cell transplantation in the treatment of chronic myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 126-128, 2014.
Article
de Zh
| WPRIM
| ID: wpr-295695
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the curative effect of imatinib and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the treatment of chronic myeloid leukemia (CML).</p><p><b>METHODS</b>292 CML patients received imatinib, and 141 patients underwent allo-HSCT. The clinical data of these patients were retrospectively analyzed to compare event- free survival (EFS) and overall survival (OS) between these two groups of patients in chronic and advanced (including accelerate and blast) phases.</p><p><b>RESULTS</b>(1) EFS, OS, expected 5- year EFS and OS of imatinib group (278 patients in chronic phase) were all statistically higher than of allo-HSCT group (120 patients in chronic phase) (88.5% vs 70.0%, 93.2% vs 80.0%, 84.0% vs 75.0% and 92.0% vs 79.0%, respectively, all P values < 0.01). (2) EFS and OS of imatinib group (14 patients in accelerate and blast phases) were 42.9% and 42.9%, respectively. Meanwhile EFS and OS of allo-HSCT group (21 patients in accelerate and blast phases) were 47.6% and 57.1%, respectively. There were no significant differences in terms of EFS and OS between the two groups (P values>0.05).</p><p><b>CONCLUSION</b>EFS and OS of imatinib group were significantly higher than of allo-HSCT group for CML patients of in chronic phase. Imatinib and allo-HSCT had the similar efficacy for CML patients in accelerate and blast phases.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pipérazines
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Pyrimidines
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Thérapeutique
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Transplantation homologue
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Benzamides
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Leucémie myéloïde chronique BCR-ABL positive
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Études rétrospectives
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Transplantation de cellules souches hématopoïétiques
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Survie sans rechute
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Utilisations thérapeutiques
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2014
Type:
Article