Analyses of risk factors for intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
; (12): 1020-1023, 2013.
Article
de Zh
| WPRIM
| ID: wpr-295749
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk factors of intestinal acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>The clinical data of 534 cases of 533 patients undergoing allo-HSCT during Jan 2004 and Sep 2012 were retrospectively analyzed. The effects of donor-recipient HLA mismatching, recipient age, donor age, donor-recipient sex combination, donor-recipient relationship, HSC source, conditioning regimen with or without total body irradiation (TBI) and HLA loci on intestinal aGVHD with different severity were analyzed by Logistic regression.</p><p><b>RESULTS</b>Intestinal aGVHD occurred in 123(23.0%) cases, with 86(16.1%) cases of stage 1 intestinal aGVHD(16.1%) and 37(6.9%) cases of stage 2 to 4 intestinal aGVHD. Multivariate analysis showed that donor-recipient HLA mismatching (OR=2.519, P=0.002), increasing donor age (OR=1.034, P=0.003), female donor for male recipient (OR=1.855, P=0.007) were risk factors for intestinal aGVHD, HLA-B38 (OR=0.256, P=0.032) was its protective factor. Donor-recipient HLA mismatching (OR=2.799, P=0.011), increasing donor age (OR=1.045, P=0.012), HLA-A1 (OR=4.157, P=0.002), A30 (OR=3.143, P=0.005) were risk factors for stage 2 to 4 intestinal aGVHD.</p><p><b>CONCLUSION</b>Occurrence of intestinal aGVHD and its severity are associated with donor-recipient HLA mismatching, donor age, donor-recipient sex relationships and some HLA loci.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Donneurs de tissus
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Transplantation homologue
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Épidémiologie
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Études rétrospectives
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Facteurs de risque
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Transplantation de cellules souches hématopoïétiques
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Maladie du greffon contre l'hôte
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Maladies intestinales
Type d'étude:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limites du sujet:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2013
Type:
Article