The Predictive Value of Baseline HBsAg Level and Early Response for HBsAg Loss in Patients with HBeAg-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 177-184, 2017.
Article
de En
| WPRIM
| ID: wpr-296499
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment.</p><p><b>METHODS</b>A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators (HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment.</p><p><b>RESULTS</b>The median treatment time for HBsAg loss was 84 weeks (7-273 weeks), and 74.38% (90 cases) of the patients needed extended treatment (> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant (B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss (B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005).</p><p><b>CONCLUSION</b>Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment.</p>
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Antiviraux
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Polyéthylène glycols
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Sang
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Protéines recombinantes
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ADN viral
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Calendrier d'administration des médicaments
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Études rétrospectives
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Interféron alpha
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Hépatite B chronique
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Utilisations thérapeutiques
Type d'étude:
Observational_studies
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Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
langue:
En
Texte intégral:
Biomedical and Environmental Sciences
Année:
2017
Type:
Article