Effect of simian vacuolating virus 40 on development and differentiation of dendritic cells from Rhesus macaque / 病毒学报
Chinese Journal of Virology
; (6): 344-348, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-297950
Responsable en Bibliothèque :
WPRO
ABSTRACT
To study the effect of simian vacuolating virus 40 (SV40) on development and differentiation of dendritic cells (DC) from rhesus macaque, the peripheral blood-derived dendritic cells from rhesus monkey were pulsed with inactivated SV40 and infective SV40, respectively at the 5th day post DC cultivation. Expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface at the 7th, 9th day post DC cultivation were analyzed by flow cytometry (FCM). The results showed that expressions of CD1a, HLA-DR, CD86 and CD83 on the cell surface in the inactivated SV40-pulsed experimental group were higher than those in the infective SV40-pulsed experimental group (P < 0.05). These cell surface molecules represented characteristic development and differentiation phase of DC. Down-regulation of expressions of these cell surface molecules indicated that infective SV40 might hamper differentiation and maturation of dendritic cells from rhesus monkey.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Physiologie
/
Virologie
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Cellules dendritiques
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Immunoglobulines
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Glycoprotéines membranaires
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Antigènes HLA-DR
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Antigènes CD
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Différenciation cellulaire
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Cellules cultivées
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Virus simien 40
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Chinese Journal of Virology
Année:
2009
Type:
Article