Correlation between major histocompatibility complex class I-related chain A gene alleles and graft rejection in small intestine, liver and kidney transplantation / 中华外科杂志
Chinese Journal of Surgery
; (12): 1070-1074, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-299764
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between major histocompatibility complex (MHC) class I chain-related gene A (MICA) gene alleles matching rates and graft rejection in small intestine, liver and kidney transplantation.</p><p><b>METHODS</b>Genome DNA were extracted from blood samples or pathological sections collected from donors and recipients of living-related transplantation, included 4 cases of small bowel transplantation, 5 cases of liver transplantation and 6 cases of kidney transplantation. The correlation between MICA alleles matching rates and acute graft rejection was analyzed following 13 MICA alleles determination by polymerase chain reaction based on sequence-specific primers (PCR-SSP).</p><p><b>RESULTS</b>HLA zygosity of all donors and recipients was confirmed to be half-matching. The recipients displaying higher matching rates of MICA alleles with donors showed lighter clinical and pathological rejection and longer survival time. On the contrary, recipients with lower matching rates of MICA alleles with donors showed severer clinical and pathological rejection and shorter survival time relatively.</p><p><b>CONCLUSION</b>Matching rates of MICA alleles has negative relevance to acute rejection, and positive relevance to survival time of recipients in small bowel, liver, and kidney transplantation.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Transplantation
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Antigènes d'histocompatibilité de classe I
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Transplantation d'organe
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Transplantation rénale
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Transplantation hépatique
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Donneur vivant
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Allèles
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Allergie et immunologie
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Génétique
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Rejet du greffon
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Surgery
Année:
2009
Type:
Article