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Preparation of baicalin-chitooligosaccharide compound and its characterization / 中国中药杂志
Zhongguo Zhong Yao Za Zhi ; (24): 648-652, 2014.
Article de Zh | WPRIM | ID: wpr-300175
Bibliothèque responsable: WPRO
ABSTRACT
To apply chitooligosaccharide in the preparation of baicalin compound, in order to increase the drug dissolution in vitro, and investigate the basic property of the compound. Baicalin-chitooligosaccharide compound was prepared by using the solvent method. The structure and physicochemical properties of compound were analyzed by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and infrared vibrational spectrum (IR), and its dissolution behavior was also investigated. The results showed that the compound prepared at baicalin-chitooligosaccharide molar ratio of 1 : 1 could significantly improve the dissolution of baicalin. The results of DSC and XRD analysis suggested that baicalin may exist in an amorphous state. IR results indicated the interaction between baicalin and chitooligosaccharide. The baicalin-chitooligosaccharide compound could significantly improve dissolution in vitro of drug.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Oligosaccharides / Flavonoïdes / Calorimétrie différentielle à balayage / Vecteurs de médicaments / Médicaments issus de plantes chinoises / Chimie / Chimie pharmaceutique / Spectroscopie infrarouge à transformée de Fourier langue: Zh Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2014 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Oligosaccharides / Flavonoïdes / Calorimétrie différentielle à balayage / Vecteurs de médicaments / Médicaments issus de plantes chinoises / Chimie / Chimie pharmaceutique / Spectroscopie infrarouge à transformée de Fourier langue: Zh Texte intégral: Zhongguo Zhong Yao Za Zhi Année: 2014 Type: Article