Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113) / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 211-213, 2005.
Article
de Zh
| WPRIM
| ID: wpr-300334
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of urokinase-type plasminogen activator (uPA) in human tongue squamous carcinoma cells (Tca8113) under hypoxia, in order to explore the relation between hypoxia and invasion and metastasis of oral cancer.</p><p><b>METHODS</b>Under different hypoxic times(0, 3, 6, 12, 24 h), the expression of uPA protein was examined quantitatively using immunohistochemical technique (IH) and flow cytometry (FCM).</p><p><b>RESULTS</b>Hypoxia promoted the expression of uPA. The longer hypoxic time was, the higher expression of uPA was.</p><p><b>CONCLUSION</b>Hypoxia can promote invasion and metastasis of oral squamous carcinoma through stimulating the expression of uPA.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la bouche
/
Tumeurs de la langue
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Carcinome épidermoïde
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Activateur du plasminogène de type urokinase
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Invasion tumorale
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
West China Journal of Stomatology
Année:
2005
Type:
Article