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Safety and effectiveness of tumor-ablative chemotherapy combined with low intensity modified conditioning regimen for 30 patients with hematologic malignancies receiving allogeneic hematopoietic stem cell transplantation / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1047-1052, 2014.
Article de Zh | WPRIM | ID: wpr-302350
Bibliothèque responsable: WPRO
ABSTRACT
This study was aimed to investigate the safety and effectiveness of tumor-ablative Chemotherapy combined with low intensity conditioning regiment BUCy/TBICy for patients with hematologic malignancies receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 30 patients with hematologic malignancies received above-mentioned therapeutic method from January 2012 to January 2013 was analyzed retrospectively, and the engraftment, GVHD, infection, conditioning-related toxicity, relapse and survival rates were evaluated. All the patients signed the informed consent before transplantation. The median follow-up duration was 20.5 (16.3-27.3) months. The results indicated that all the patients had been engrafted successfully. One year overall survival (OS) and disease-free survival (DFS) rates were 93.3% and 83.3% respectively. No conditioning-related toxicity occurred. The incidences of II-IV grade aGVHD was 37.9%, among which incidence of III-IV grade aGVHD was 3.4%; incidence of extensive cGVHD was 13.8%. So far, 1 case relapsed, 1 case displayed graft rejection, and poor function of graft occurred in 1 case, death occurred in 2 cases(6.7%). It is concluded that tumor-ablative chemotherapy combined with low intensity-modified BUCy/TBICy is safe and effective in allogeneic hematopoietic stem cell transplantation for hematologic malignancies, and it is useful to reduce relapse of hematologic malignancies after transplantation.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Transplantation homologue / Protocoles de polychimiothérapie antinéoplasique / Études rétrospectives / Résultat thérapeutique / Transplantation de cellules souches hématopoïétiques / Tumeurs hématologiques / Conditionnement pour greffe / Utilisations thérapeutiques / Méthodes Type d'étude: Observational_studies Limites du sujet: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2014 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Transplantation homologue / Protocoles de polychimiothérapie antinéoplasique / Études rétrospectives / Résultat thérapeutique / Transplantation de cellules souches hématopoïétiques / Tumeurs hématologiques / Conditionnement pour greffe / Utilisations thérapeutiques / Méthodes Type d'étude: Observational_studies Limites du sujet: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2014 Type: Article