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Protective effects of sodium beta-aescin on ischemia-reperfusion injury in rat brain / 药学学报
Yao Xue Xue Bao ; (12): 419-423, 2004.
Article de En | WPRIM | ID: wpr-302795
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>AIM</b>To investigate the protective effects of sodium beta-aescin on cerebral ischemia-reperfusion injury in rats.</p><p><b>METHODS</b>Rats were pretreated with sodium beta-aesein for 7 d and then subjected to cerebral ischemia-reperfusion injury induced by a middle cerebral artery occlusion (MCAO). The neurological outcome was evaluated by the Longa's method; The infarct volume was assessed by hemmatoxylin-Eosin staining and the cerebral water content was measured by dry weight method. The activities of SOD, GSH-Px, CAT, Na+ -K+ -ATPase and the MDA content were measured in the cortex and hippocampus of ischemic and non-ischemic hemisphere.</p><p><b>RESULTS</b>Sodium beta-aescin significantly reduced the volume of cerebral infarct and water content, and ameliorated the neurological deficit (P < 0.05). In vehicle-treated rats, the activities of SOD, GSH-Px and Na+ -K+ -ATPase in the cortex and hippocampus of ischemic hemisphere were all decreased (P < 0.01) , while the CAT activity was slightly elevated and the MDA of content was significantly increased (P < 0.01) compared with the sham-operated group. After treated with sodium beta-aescin, the effects on recovery of SOD, GSH-Px, Na+ -K+ -ATPase activities were observed (P < 0.05), and the MDA content was reduced (P < 0.05).</p><p><b>CONCLUSION</b>These results showed that pretreatment with sodium beta-aescin can attenuate brain injury and its antioxidant activity on rats which encountered cerebral ischemia-reperfusion.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Pharmacologie / Superoxide dismutase / Encéphale / Lésion d'ischémie-reperfusion / Catalase / Encéphalopathie ischémique / Rat Sprague-Dawley / Sodium-Potassium-Exchanging ATPase / Neuroprotecteurs Limites du sujet: Animals langue: En Texte intégral: Yao Xue Xue Bao Année: 2004 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Pharmacologie / Superoxide dismutase / Encéphale / Lésion d'ischémie-reperfusion / Catalase / Encéphalopathie ischémique / Rat Sprague-Dawley / Sodium-Potassium-Exchanging ATPase / Neuroprotecteurs Limites du sujet: Animals langue: En Texte intégral: Yao Xue Xue Bao Année: 2004 Type: Article