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FSH and FSHR gene polymorphisms and male infertility: An update / 中华男科学杂志
Zhonghua nankexue ; Zhonghua nankexue;(12): 1031-1034, 2015.
Article de Zh | WPRIM | ID: wpr-304776
Bibliothèque responsable: WPRO
ABSTRACT
Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Cellules de Sertoli / Spermatogenèse / Testicule / Récepteur FSH / Polymorphisme de nucléotide simple / Hormone folliculostimulante / Génétique / Infertilité masculine Limites du sujet: Humans / Male langue: Zh Texte intégral: Zhonghua nankexue Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Cellules de Sertoli / Spermatogenèse / Testicule / Récepteur FSH / Polymorphisme de nucléotide simple / Hormone folliculostimulante / Génétique / Infertilité masculine Limites du sujet: Humans / Male langue: Zh Texte intégral: Zhonghua nankexue Année: 2015 Type: Article