Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 688-690, 2009.
Article
de Zh
| WPRIM
| ID: wpr-306701
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To provide right time points in selection of right aged animals and the normal physiological data of TX mice.</p><p><b>METHODS</b>7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured. The liver histopathology was observed under light microscopy and electron microscope.</p><p><b>RESULTS</b>Transaminase increased significantly only in 10 and 11-month- old (AST(TX10) = 218.3 U/L, AST(TX11) = 197.5 U/L, AST(DL10) = 171.5 U/L, AST(DL11) = 165.0 U/L, P(10) less than 0.001, P(11) = 0.022), but the copper concentration of liver, brain and kidney was significantly increased during 7-12 month old (the average concentration of copper, Liver(TX) = (750.0 +/- 85.5) mg/kg, Brain(TX) = (39.7 +/- 2.2)mg/kg, Kidney(TX) = (29.8 +/- 5.0) mg/kg, Liver(DL) = (11.6 +/- 1.5) mg/kg, Brain(DL) = (16.8 +/- 0.9) mg/kg, Kidney(DL) = (14.2 +/- 1.0) mg/kg, t = 21.16, 23.60, 7.47, for all these organs P less than 0.05).</p><p><b>CONCLUSION</b>TX mice is a suitable model of liver disease with natural recovery, so selecting animal model of suitable time point is very important.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Aspartate aminotransferases
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Facteurs temps
/
Sang
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Encéphale
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Céruloplasmine
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Cuivre
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Modèles animaux de maladie humaine
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Rein
/
Foie
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Chinese Journal of Hepatology
Année:
2009
Type:
Article