Near infrared analysis of blending homogeneity of Chinese medicine formula particles based on moving window F test method / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3557-3562, 2016.
Article
Dans Zh
| WPRIM
| ID: wpr-307121
Responsable en Bibliothèque :
WPRO
ABSTRACT
Blending uniformity is essential to ensure the homogeneity of Chinese medicine formula particles within each batch. This study was based on the blending process of ebony spray dried powder and dextrin(the proportion of dextrin was 10%),in which the analysis of near infrared (NIR) diffuse reflectance spectra was collected from six different sampling points in combination with moving window F test method in order to assess the blending uniformity of the blending process.The method was validated by the changes of citric acid content determined by the HPLC. The results of moving window F test method showed that the ebony spray dried powder and dextrin was homogeneous during 200-300 r and was segregated during 300-400 r. An advantage of this method is that the threshold value is defined statistically, not empirically and thus does not suffer from threshold ambiguities in common with the moving block standard deviatiun (MBSD). And this method could be employed to monitor other blending process of Chinese medicine powders on line.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2016
Type:
Article