Analysis of Y-chromosomal biallelic polymorphisms in Sichuan Han of Chinese population / 中华医学遗传学杂志
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; (6): 352-355, 2008.
Article
de Zh
| WPRIM
| ID: wpr-308061
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the forensic utility of Y-single nucleotide polymorphisms (SNPs) markers.</p><p><b>METHODS</b>Allele-specific PCR, restriction enzyme digestion or direct PCR were performed to examine 10 different SNP loci on Y chromosome, namely M9, M15, M45, M89, M95, M122, M134, M145, M173 and P25 in 161 Chinese Han males.</p><p><b>RESULTS</b>A total of 8 of the 10 SNPs are reported to be polymorphic in Chinese. The gene diversity for the loci showing polymorphism ranged from 0.988/0.012-0.752/0.248, with a power of discrimination 0.094-0.373. Loci M122 and M134 were the most polymorphic markers in Chinese Hans. Nine different haplogroups with frequencies from 1.2% to 51.6% were observed and 3 of the haplogroups-K*(x O2a, O3, P), O3*(x O3e) and O3e were found in 75.2% of Chinese Hans.</p><p><b>CONCLUSION</b>A comprehensive gene diversity data of Y chromosome and haplogroups were obtained in Sichuan Han population, which will be served as the base for using these Y-SNP markers in forensic medicine and individual identification in Sichuan Hans.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
/
Haplotypes
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Chine
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Réaction de polymérisation en chaîne
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Chromosomes Y humains
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Génétique
Limites du sujet:
Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Année:
2008
Type:
Article