Risks and benefits: new concepts of treatment of late-onset hypogonadism / 中华男科学杂志
National Journal of Andrology
; (12): 483-489, 2014.
Article
de Zh
| WPRIM
| ID: wpr-309687
Bibliothèque responsable:
WPRO
ABSTRACT
Late-onset hypogonadism (LOH) is a clinical and bio-chemical syndrome associated with advancing age in males and seriously affects the quality of life of some of the patients. A classical therapeutic option for LOH is testosterone supplementary treatment (TST). Its effectiveness has been verified, whereas its long-term safety remains to be further evaluated. With deeper insights into LOH, many new therapeutic strategies have been proposed, which include the treatments with gonadotropins, testosterone precursors (such as dehydroepiandrosterone [DHEA]), non-aromatizable androgens (such as dihydrotestosterone [DHT]), antiestrogens (such as aromatase inhibitors and estrogen receptor antagonists), and Chinese medicine. Meanwhile, studies on the transplantation of Leydig stem cells, selective androgen receptor modulators (SARMs), and selective estrogen receptor beta (ERbeta) agonists have shed new light on the treatment of LOH.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Chirurgie générale
/
Testostérone
/
Thérapeutique
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Hypogonadisme
Type d'étude:
Etiology_studies
Limites du sujet:
Humans
/
Male
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2014
Type:
Article