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Curative effect of Yidu Recipe in treating chronic hepatitis B patients of gan-shen yin-deficiency and damp-heat syndrome type and its influence of T-cell subsets / 中国中西医结合杂志
Article de Zh | WPRIM | ID: wpr-313187
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Yidu Recipe (YDR) in treating patients of chronic hepatitis B (CHB) with positive hepatitis B e-antigen (HBeAg) and its influence on the quantity and function of T-cell subsets.</p><p><b>METHODS</b>Fifty-seven CHB patients measured up the inclusive criteria were randomly assigned to the control group and the treated group, treated respectively by entecavir alone and entecavir + YDR for 6 months. Changes of alanine a minotransferase (ALT), aspartate a minotransferase (AST), HBV-DNA, HBV-M, interleukin-4 (IL-4) and Chinese medicine syndrome score, as well as amounts of natural killer (NK) T cell, gamma-interferon (gamma-IFN), Th1, Th2, Tc1 and Tc2 cells in peripheral blood (detected by flow cytometry) before and after treatment were observed. And the liver function normalization rate, negative inversion rates of HBV-DNA and HBeAg were estimated at terminal of the trial.</p><p><b>RESULTS</b>Seven cases were dropped out in the observation period. Compared with the control group, levels of ALT, AST, HBV-DNA and Chinese medicine syndrome score were lower after treatment (P < 0.05), and liver function normalization rate was higher in the treated group, while the difference between groups in negative inversion rates HBV-DNA and HBeAg were insignificant (P > 0.05). Amount of IFN-gamma increased, IL-4 reduced, and Tc1 cell raised after treatment, which led to the rise of Tcl/Tc2 ratio in both groups; while in the treated group, in addition to the above-mentioned changes, the Th1 cell was increased also, and thus to make elevation of Th1/Th2 ratio (P < 0.05).</p><p><b>CONCLUSION</b>The efficacy of entecavir + YDR in treating HBeAg positive CHB patients is better than that of entecavir alone. YDR can effectively improve patients' liver function, inhibit HBV-DNA replication and improve clinical symptoms, its action may be realized by way of increasing the amount of NKT cells, inducing increase of IFN-gamma and decrease of IL-4 secretions, and regulating the balance between Th1/Th2 and Tc1/Tc2.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Antiviraux / Médicaments issus de plantes chinoises / Sous-populations de lymphocytes T / Déficit du Yin / Hépatite B chronique / Utilisations thérapeutiques / Diagnostic différentiel / Traitement médicamenteux / Association de médicaments / Allergie et immunologie Type d'étude: Diagnostic_studies Limites du sujet: Adult / Female / Humans / Male langue: Zh Texte intégral: Zhongguo Zhong Xi Yi Jie He Za Zhi Année: 2010 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Antiviraux / Médicaments issus de plantes chinoises / Sous-populations de lymphocytes T / Déficit du Yin / Hépatite B chronique / Utilisations thérapeutiques / Diagnostic différentiel / Traitement médicamenteux / Association de médicaments / Allergie et immunologie Type d'étude: Diagnostic_studies Limites du sujet: Adult / Female / Humans / Male langue: Zh Texte intégral: Zhongguo Zhong Xi Yi Jie He Za Zhi Année: 2010 Type: Article