Early biological markers of manganese exposure / 中华劳动卫生职业病杂志
Zhonghua laodong weisheng zhiyebing zazhi
; Zhonghua laodong weisheng zhiyebing zazhi;(12): 645-647, 2010.
Article
de Zh
| WPRIM
| ID: wpr-313499
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the biomarker of manganese exposure by analyzing the relationship between manganese exposure and concentration in some biomaterials.</p><p><b>METHODS</b>The air samples were collected through the individual air sample. According to the manganese levels in the air, workers were assigned to control group, low concentration group and high concentration group, and manganese in the hair, urine, serum, blood cell and saliva from different group were measured respectively. The correlations between concentration of external manganese exposure and manganese concentrations in biomaterials, and years of employment and concentrations in biomaterials were analyzed.</p><p><b>RESULTS</b>In the high concentration group, saliva manganese was 32.17 µg/L, hair manganese was 37.39 mg/kg, urine manganese was 2.50 µg/L, plasma manganese was 29.61 µg/L, blood manganese was 14.49 µg/L, were higher than those in the control group (10.40 µg/L, 1.60 mg/kg, 0.77 µg/L, 10.30 µg/L, 4.56 µg/L respectively) (P < 0.01). The manganese concentration in the saliva was significantly correlated with airborne manganese concentration (r = 0.649, P < 0.01), with the years of employment (r = 0.404, P < 0.01), with the total exposure of manganese (r = 0.342, P < 0.01), with the manganese concentration of plasma (r = 0.303, P < 0.01) and with the manganese concentration in blood cells (r = 0.359, P < 0.01), respectively.</p><p><b>CONCLUSIONS</b>The concentration of manganese in saliva could work as a biomarker of manganese internal exposure.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Salive
/
Urine
/
Sang
/
Marqueurs biologiques
/
Chimie
/
Exposition professionnelle
/
Intoxication au manganèse
/
Polluants atmosphériques d'origine professionnelle
/
Poils
/
Manganèse
Limites du sujet:
Adult
/
Humans
langue:
Zh
Texte intégral:
Zhonghua laodong weisheng zhiyebing zazhi
Année:
2010
Type:
Article