Analysis the relationship of HBV BCP A1762T/G1764A double mutation with HBV related acute on chronic liver failure / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 190-192, 2010.
Article
de Zh
| WPRIM
| ID: wpr-316927
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analysis the relationship between HBV BCP A1762T/G1764A double mutation with acute on chronic liver failure (ACLF).</p><p><b>METHODS</b>HBV BCP A1762T/G1764A double mutation was detected in 166 HBV chronic infection patients by nested PCR and direct DNA sequencing. The mutation rate was compared among the patients with different disease course.</p><p><b>RESULTS</b>Among 166 patients, 45 patients, 45 patients, 49 patients and 27 patients were diagnosed as chronic hepatitis B (CHB), liver cirrhosis (LC), ACLF and hepatocellular carcinoma (HCC), respectively. A1762T/G1764A double mutation rate was 40.0% (18/45), 84.4% (38/45), 73.5% (36/49) and 92.6% (25/27) respectively in different groups. However, A1762T/G1764A double mutation rate has no difference between ACLF based on CHB and LC (P = 0.502) and between patients with HBeAg positive and negative (P = 0.735). HBV DNA level (log) of patients with A1762T/G1764A double mutation was 5.68 +/- 1.36, lower than but having no significant statistic difference compared to patients without the double mutation (6.14 +/- 1.81, P = 0.075).</p><p><b>CONCLUSION</b>A1762T/G1764A double mutation has a close relationship with the progress of HBV-infection diseases, but is not specific to patients with ACLF. And patients with BCP double mutation have similar HBV DNA levels and HBeAg status with patients without the double mutation.</p>
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
ADN viral
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Protéines du core viral
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Virus de l'hépatite B
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Statistiques comme sujet
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Régions promotrices (génétique)
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Défaillance hépatique aigüe
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Hépatite B chronique
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Maladie du foie en phase terminale
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Génétique
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Génotype
Limites du sujet:
Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2010
Type:
Article