Progress in the study of some important natural bioactive cyclopeptides / 药学学报
Acta Pharmaceutica Sinica
; (12): 271-279, 2012.
Article
Dans Zh
| WPRIM
| ID: wpr-323046
Responsable en Bibliothèque :
WPRO
ABSTRACT
Natural cyclopeptides are hot spots in chemical and pharmaceutical fields because of the wide spreading bio-resources, complex molecular structures and various bioactivities. Bio-producers of cyclopeptides distribute over almost every kingdom from bacteria to plants and animals. Many cyclopeptides contain non-coded amino acids and non-pepditic bonds. Most exciting characteristic of cyclopeptides is a range of interesting bioactivities such as antibiotics gramicidin-S (2), vancomycin (3) and daptomycin (4), immunosuppressive cyclosporin-A (1) and astin-C (8), and anti-tumor aplidine (5), RA-V (6) and RA-VII (7). Compounds 1-4 are being used in clinics; compounds 5-8 are in the stages of clinical trial or as a candidate for drug research. In this review, the progress in chemical and bioactive studies on these important natural bioactive cyclopeptides 1-8 are introduced, mainly including discovery, bioactivity, mechanism, QSAR and synthesis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peptides cycliques
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Pharmacologie
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Vancomycine
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Structure moléculaire
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Chimie
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Immunosuppression thérapeutique
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Ciclosporine
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Daptomycine
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Relation quantitative structure-activité
/
Utilisations thérapeutiques
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
/
Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article