Clinical characteristics and therapy of pan-drug resistant Acinetobacter baumannii infection / 南方医科大学学报
Journal of Southern Medical University
; (12): 2351-2359, 2010.
Article
Dans Zh
| WPRIM
| ID: wpr-323663
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze clinical characteristics and therapy of pan-resistant Acinetobacter baumannii (PDRAB) infection and explore the methods for effective therapy and prevention of this infection.</p><p><b>METHODS</b>Nine hospitalized patients with PDRAB infection confirmed by pathogen and susceptibility testing were analyzed for the risk factors and the treatment outcomes were assessed by case analysis.</p><p><b>RESULTS</b>PDRAB infections occurred mainly in patients with severe complications, most of whom had complications by diabetes or hypertension or damaged mucosal integrity due to mechanical ventilation, surgery and catheterization. The polymyxin sensitivity were 100% for these infections, but all the bacteria identified showed a antimicrobial resistance rates of 100%. The majority of the infections were acquired during hospitalization occurring mainly in the lungs; all the patients had prolonged hospitalization and received antibiotic treatments with high proportions of broad-spectrum antimicrobial agents especially third-generation cephalosporins and quinolones. Exclusive or sequential use of carbapenems and sulbactam in combination with quinolone or aminoglycoside produced favorable effects.</p><p><b>CONCLUSIONS</b>The prevalence of hospital-acquired pan-resistance of PDRAB infections increased significantly in recent years, particularly in patients with high risk factors. The widespread use of broad-spectrum antibiotics may have some relevance to drug resistant occurrence. The application of carbapenems or sulbactam, or their sequential use, in combination with other agents may produce good effects.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Infections à Acinetobacter
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Tests de sensibilité microbienne
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Infection croisée
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Multirésistance bactérienne aux médicaments
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Acinetobacter baumannii
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Utilisations thérapeutiques
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Traitement médicamenteux
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Microbiologie
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Anti-infectieux
Type d'étude:
Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article