Controlled clinical trials on the pathological expressions of VEGF in patients with active ankylosing spondylitis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 649-650, 2008.
Article
de Zh
| WPRIM
| ID: wpr-324025
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the pathological expression and significance of VEGF in patients with active ankylosing spondylitis.</p><p><b>METHODS</b>The expression of VEGF in the synovial tissues of cacroiliac joint of patients with active AS was detected by using in situ hybridization and the results were compared with those in the patients with pelvic fracture using image analysis system.</p><p><b>RESULTS</b>The positive expressions of VEGF in the synovial tissues of cacroiliac joint of patients with active AS were stronger than those in the control group (P<0.01).</p><p><b>CONCLUSION</b>VEGF are important factors in patients with active AS. They are tightly correlated with the process of osteoclasia and pathological new bone formation in the cacroiliac joint of patients with active AS. If we can reduce the expressions of VEGF in the patients with active AS, the process of osteoclasia and pathological new bone formation will be interrupted and this provides a new strategy for the treatment of ankylosing spondylitis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pelvispondylite rhumatismale
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Synovie
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ARN messager
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Études cas-témoins
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Régulation de l'expression des gènes
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Biologie cellulaire
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Facteur de croissance endothéliale vasculaire de type A
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Génétique
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Métabolisme
Type d'étude:
Observational_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
China Journal of Orthopaedics and Traumatology
Année:
2008
Type:
Article