Effect of niupo zhibao pellet on transforming growth factor-beta1 and its receptor's expression in endotoxic shock rats with lung injury / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 613-616, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-326683
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the influence of Niupo Zhibao pellet (NZP) on transforming growth factor-beta1 (TGF-beta1) and its receptor's expression.</p><p><b>METHODS</b>Endotoxic shock model was established by intravenous injection of lipopolysaccharide (LPS) 1.5 mg/kg and intraperitoneal injection of D-galactosamine 100 mg/kg, and intervened by NZP, TGF-beta1 and its receptor's expression in lung tissue were detected by immunohistochemical method.</p><p><b>RESULTS</b>NZP could enhance the TGF-beta1 and its receptor's expression in endotoxic shock lung tissue, and reduce the injury of lung.</p><p><b>CONCLUSION</b>The mechanism of NZP in reducing endotoxic shock lung injury is possibly related with its effect in enhancing the TGF-beta1 and its receptor's expression in lung tissue.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Choc septique
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Médicaments issus de plantes chinoises
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Lipopolysaccharides
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Facteur de croissance transformant bêta
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Rat Sprague-Dawley
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Récepteurs TGF-bêta
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Facteur de croissance transformant bêta-1
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Galactosamine
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2004
Type:
Article