Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方) / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 459-463, 2011.
Article
de En
| WPRIM
| ID: wpr-328485
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anticancer activity of the total flavonoids isolated from a herbal formula, Xianhe Yanling Recipe (仙鹤延龄方), a recipe commonly used in cancer patients in China.</p><p><b>METHODS</b>The in vitro anticancer activity of the total flavonoids was determined using the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on three cancer cell lines: MCF-7 (a human breast adenocarcinoma cell line), HepG-2 (a human hepatocellular carcinoma cell line) and ES-2 (a human ovarian cancer cell line). The in vivo anticancer effect of the total flavonoids was assessed in a mouse tumor model bearing H22-induced hepatocellular carcinoma, and cisplatin was used as a positive control.</p><p><b>RESULTS</b>The total flavonoids exerted a powerful inhibitory effect on the three cell lines, with 50% inhibiting concentrations (IC(50)) of 24.948, 31.569 and 6.923 μg/mL, respectively. In vivo studies showed that the total flavonoids had dose-dependent inhibitory effects on hepatocellular carcinoma in mice.</p><p><b>CONCLUSION</b>The total flavonoids from Xianhe Yanling Recipe have potential anticancer activity, and further researches and development are warranted.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Flavonoïdes
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Tests de criblage d'agents antitumoraux
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Médicaments issus de plantes chinoises
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Concentration inhibitrice 50
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Lignée cellulaire tumorale
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Prolifération cellulaire
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Transplantation tumorale
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Antinéoplasiques
Limites du sujet:
Animals
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Humans
langue:
En
Texte intégral:
Chinese journal of integrative medicine
Année:
2011
Type:
Article