Identification of G6PD gene variants from Hakka population in Guangdong province / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 448-451, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-328853
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Studying on G6PD polymorphism from Hakka population in Guangdong province.</p><p><b>METHODS</b>Identifying the variants of G6PD gene and determining the frequencies respectively with the use of amplified refractory mutation system(ARMS), polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP) and ABI 3100 DNA sequencing technologies.</p><p><b>RESULTS</b>Mutations of G6PD gene in cDNA 1388 (G-->A), 1376 (G-->T), 95 (A-->G), 392 (G-->T), 1024 (C-->T), 1311 (C-->T) have been found.</p><p><b>CONCLUSION</b>G6PD cDNA 1388 (G-->A), 1376 (G-->T), 95(A--> G), 392 (G-->T), 1024 (C-->T) and 1311 (C-->T) accompanied with intron 11 (93 T-->C) are the common mutations in Chinese population. cDNA 1388 (G-->A), cDNA 1376 (G-->T) are the most popular G6PD gene variants in Hakka population. In this study, no new type of G6PD gene mutation was found in the Hakkas of Guangdong.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Analyse de mutations d'ADN
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Introns
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Chine
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Réaction de polymérisation en chaîne
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Analyse de séquence d'ADN
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Polymorphisme de nucléotide simple
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Asiatiques
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Ethnologie
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Génétique
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Glucose 6-phosphate dehydrogenase
Type d'étude:
Diagnostic_studies
Limites du sujet:
Humans
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2004
Type:
Article