Expression and significance of angiopoietins in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 63-68, 2005.
Article
Dans Zh
| WPRIM
| ID: wpr-329984
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.</p><p><b>METHODS</b>The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.</p><p><b>RESULTS</b>The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P > 0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P < 0.05).</p><p><b>CONCLUSION</b>Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la bouche
/
Carcinome épidermoïde
/
Angiopoïétines
/
Angiopoïétine-1
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Angiopoïétine-2
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Muqueuse de la bouche
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Tumeurs
/
Néovascularisation pathologique
Limites du sujet:
Humans
/
Male
langue:
Zh
Texte intégral:
West China Journal of Stomatology
Année:
2005
Type:
Article