Study on unrelated donor allogeneic bone marrow transplantation with Bu-CY2 conditioning regimen for myelodysplastic syndrome / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 122-126, 2006.
Article
de Zh
| WPRIM
| ID: wpr-332187
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of Bu-CY(2) conditioning regimen on allogeneic bone marrow transplantation (BMT) with unrelated donor for myelodysplastic syndrome.</p><p><b>METHODS</b>Six patients received chemotherapy regimen of busulfan (Bu) and cyclophosphamide (CY) before allogeneic BMT (Bu 4 mg . kg(-1) . d(-1), -7 d - -4 d, CY 60 mg . kg(-1) . d(-1), -3 d - -2 d). Mycophenolate mofetil combined with cyclosporin A and methotrexate was used for prevention of acute graft-versus-host disease after transplantation. Lipo prostaglandin E(1)was used in prophylactic regimen for hepatic veno-occlusive disease.</p><p><b>RESULT</b>Neutrophil count began to be higher than 0.5 x 10(9)/Lat the 18th day after BMT. Platelet count began to be higher than 20 x 10(9)/Lat the 21st day after BMT. Disease-free survival in the six patients was 27 months.</p><p><b>CONCLUSION</b>Bu-CY(2) conditioning regimen on allogeneic bone marrow transplantation with unrelated donor is an effective therapy for patients with myelodysplastic syndrome.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Chirurgie générale
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Syndromes myélodysplasiques
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Busulfan
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Protocoles de polychimiothérapie antinéoplasique
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Transplantation de moelle osseuse
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Conditionnement pour greffe
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Cyclophosphamide
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Utilisations thérapeutiques
Limites du sujet:
Adolescent
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Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Zhejiang Daxue xuebao. Yixue ban
Année:
2006
Type:
Article