Expression of osteopontin in central nervous system leukemia and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 325-328, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-332787
Responsable en Bibliothèque :
WPRO
ABSTRACT
This study was aimed to investigate the expression of osteopontin (OPN) in central nervous system leukemia (CNSL) and to understand its clinical significance. The expression level of OPN in serum of 62 pediatric patients (22 cases of CNSL, 20 cases of acute leukemia without extramedullary infiltration and 20 cases of nontumor patients) and 19 cases of CNSL with complete remission (CR)were assayed by ELISA; the expression changes of OPN mRNA in bone marrow of the CNSL patients were detected by RT-PCR. The results indicated that the serum OPN level was significantly higher in CNSL group (25.21 ± 6.87 ng/ml) than that in acute leukemia group (13.24 ± 2.73 ng/ml) (P < 0.001) and nontumorous group (3.14 ± 1.60 ng/ml) (P < 0.001); the serum OPN level (4.35 ± 1.50 ng/ml) in CNSL group with CR decreased obviously (P < 0.001) after therapy; RT-PCR analysis showed that the expression of OPN mRNA was higher in CNSL group as compared with other two groups (P < 0.01). It is concluded that the OPN expression may play a role in central nervous system infiltration of leukemia, the mechanism of which remains to need further clinical exploration.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Sang
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Myélogramme
/
Leucémies
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Études cas-témoins
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Tumeurs du système nerveux central
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Ostéopontine
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Métabolisme
Type d'étude:
Observational_studies
Limites du sujet:
Child, preschool
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2013
Type:
Article