Treatment of late-staged pancreatic carcinoma with implantation of 125I seeds in combination with regional arterial infusion chemotherapy / 中华外科杂志
Chinese Journal of Surgery
; (12): 27-29, 2007.
Article
de Zh
| WPRIM
| ID: wpr-334416
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of combined use of implantation of (125)I seeds with regional arterial infusion chemotherapy on late-staged pancreatic carcinoma.</p><p><b>METHODS</b>During operation, (125)I seeds were implanted into tumor parenchyma or operative beds for 7 patients with pathological diagnosis of late-staged pancreatic carcinoma, then chemotherapy pump was implanted into common hepatic artery or celiac artery through left gastric artery or right epigastric artery. Gemcitabine (1000 mg/m(2)) plus fluorouracil (500 mg/m(2)) was used for postoperative adjuvant chemotherapy once a week for 7 consecutive weeks.</p><p><b>RESULTS</b>The mean number of implanted (125)I seeds was 42 and the mean dose was 29.4 mCi. The mean follow-up time was 245 days. Rate of pain relief was 100%, metastasis foci was reduced in 2 cases. CA-19-9 Antigen level decreased to normal in all patients. Pancreatic fistula occurred in one case and was cured with conservative therapy.</p><p><b>CONCLUSIONS</b>The combination therapy is effective for late-staged pancreatic carcinoma, it brings symptom relief and improvement in quality of life.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs du pancréas
/
Thérapeutique
/
Curiethérapie
/
Perfusions artérielles
/
Protocoles de polychimiothérapie antinéoplasique
/
Analyse de survie
/
Études rétrospectives
/
Études de suivi
/
Résultat thérapeutique
/
Traitement médicamenteux adjuvant
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Aged
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Surgery
Année:
2007
Type:
Article