Protective effect of pentoxifylline on spermatogenesis following testicular torsion/detorsion in rats / 中华男科学杂志
National Journal of Andrology
; (12): 323-329, 2006.
Article
Dans Zh
| WPRIM
| ID: wpr-338302
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of pentoxifylline on spermatogenesis following testicular torsion/detorsion in rats.</p><p><b>METHODS</b>Healthy male Sprague-Dawley rats (n = 24) were divided into three groups randomly, each comprising 8 rats. In Group I, rats underwent a sham operation. In Group II and III, animals were submitted to unilateral 720 degrees testicular torsion, then detorsion in two hours. Infusion of isotonic saline and pentoxifylline into tail vein was initiated 15 minutes prior to relief of torsion in Group II and III respectively. Twenty four hours later, testes were examined for evidence of germ cell apoptosis by the flow cytometry and the level of total antioxidant capability (T-AOC) and malondialdehyde (MDA) by spectrophotometry.</p><p><b>RESULTS</b>Compared with that of group II, the number of apoptotic germ cell and the level of MDA decreased remarkably in Group III, but T-AOC increased significantly (P <0.01).</p><p><b>CONCLUSION</b>Pentoxifylline provided significant rescue of testicular function after acute experimental torsion.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Pentoxifylline
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Pharmacologie
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Torsion du cordon spermatique
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Spermatogenèse
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Vasodilatateurs
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Répartition aléatoire
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Rat Sprague-Dawley
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Apoptose
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Traitement médicamenteux
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2006
Type:
Article