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Down-regulation of human leukocyte antigens class I on peripheral T lymphocytes and NK cells from subjects in region of high-incidence gastrointestinal tumor / 中华医学杂志(英文版)
Chin. med. j ; Chin. med. j;(24): 1813-1817, 2011.
Article de En | WPRIM | ID: wpr-338582
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>BACKGROUND</b>Many types of human tumors can suppress the immune system to enhance their survival. Loss or down-regulation of human leukocyte antigens (HLA) class I on tumors is considered to be a major mechanism of tumor immune escape. Our previous studies found that HLA class I on peripheral-blood mononuclear cells was significantly lower in gastric cancer patients. The present study made an analysis of HLA class I expression on peripheral-blood T lymphocytes and NK cells from subjects of Lijiadian village, a village with high-incidence gastrointestinal tumor.</p><p><b>METHODS</b>A total of 181 villagers from Lijiadian village and 153 normal controls from the Department of Health Examination Center were enrolled in this study. Using a multi-tumor markers detection system, these villagers were divided into two groups: high-risk group (tumor markers positive group) and low-risk group (tumor markers negative group). The percentage of T lymphocytes and NK cells and levels of HLA class I on their surface were determined in these subjects by flow cytometry.</p><p><b>RESULTS</b>Percentages of T lymphocytes and NK cells in peripheral-blood mononuclear cells did not vary with age. The expression level of HLA class I on peripheral T lymphocytes and NK cells was not affected by age or gender, but was significantly down-regulated in Lijiadian villagers (P < 0.05), especially on the surface of NK cells (P < 0.01). Compared with the low-risk group, there was a significant reduction of HLA class I on peripheral T lymphocytes (P < 0.05) and NK cells (P < 0.05) in the high-risk group.</p><p><b>CONCLUSIONS</b>HLA class I on peripheral T lymphocytes and NK cells may be involved in tumorigenesis and development of gastrointestinal tumor, and understanding their changes in expression may provide new insights into the mechanism of tumor immunity.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Cellules tueuses naturelles / Lymphocytes T / Antigènes d'histocompatibilité de classe I / Marqueurs biologiques tumoraux / Régulation négative / Allergie et immunologie / Tumeurs gastro-intestinales Type d'étude: Incidence_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: En Texte intégral: Chin. med. j Année: 2011 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Cellules tueuses naturelles / Lymphocytes T / Antigènes d'histocompatibilité de classe I / Marqueurs biologiques tumoraux / Régulation négative / Allergie et immunologie / Tumeurs gastro-intestinales Type d'étude: Incidence_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: En Texte intégral: Chin. med. j Année: 2011 Type: Article